Welcome to the ECHA website. Moreover, simultaneous treatment with propolis significantly modulated the toxic effects of aluminium chloride. Aluminium chloride (AlCl 3), also known as aluminium trichloride, is the main compound of aluminium and chlorine.It is white, but samples are often contaminated with iron(III) chloride, giving it a yellow color.The solid has a low melting and boiling point. O.O.O.O.O.O. 1 gm of aluminum chloride hexahydrate dissolves in 0.9 ml water and 4 ml of alcohol. However, the use of higher concentration of AlCl3, no doubt, increased the aberration frequency to some extent. © 2020 Merck KGaA, Darmstadt, Germany and/or its affiliates. Rats were orally administered the test substance at 34 mg/kg bw/day for 30 days. On top of that, cytotoxicity was not assessed and no positive control was used. Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. Sodium citrate-acetic acid alcohol - air drying - Giemsa staining methodology was followed for the preparations of bone marrow cells. A significant increase in ALP, AST, ALT and LDH and induced histopathological changes in the liver were observed in the group treated with aluminium chloride.On the contrary, treatment with propolis alone did not cause any adverse effect on above parameters. It is also soluble in glycerol, ether and propylene glycol. Furthermore, severe pathological damages were established in both liver and kidneys of Al treated rats. ALUMINIUM CHLORIDE HEXAHYDRATE Aluminii chloridum hexahydricum AlCl3,6H2O Mr 241.4 [7784-13-6] DEFINITION Content:95.0percentto101.0percent. 2.39. vapor pressure. The effect of AlCl3 on bone marrow chromosomes of mice was, therefore, non-delayed type and it continued without much change even at 72 h. In the combined data of 0.1 M series among the different types of aberration, the frequency per cell was found to be the highest for the chromatid type (0.1) and lowest for the chromosome type break (0.0024). 100°C (dec.) Density. In a study by Geyikoglu et al. Basic aluminium chloride was tested in a GLP-compliant in vitro micronucleus assay conducted according to OECD guideline 487 (NOTOX, 2010). This discrepancy undermines the results found in this study. identifies anhydrous aluminium chloride and not the hexahydrate). Aluminum Chloride Hexahydrate Safety Data Sheet according to Federal Register / Vol. Under the test conditions, aluminum chloride was considered to induce DNA damage in human peripheral blood lymphocytes by the authors. Under the test conditions, AlCl3 was considered to induce chromosomal aberrations at higher concentrations. you enter 062K1064. Store at +15°C to +25°C. Site Use Terms All tested concentrations were cytotoxic, far beyond the range recommended in OECD guideline 473, and reduced significantly the mitotic index in all phases of cell cycle. (1982) reported limited information from an in vitro mammalian cell gene mutation assay. The increase in DNA damage and apoptotic cells (cytotoxicity) was well correlated which means that the DNA damage seen could simply be a side-effect of cytotoxicity. Sigma-Aldrich Products are sold exclusively through Sigma-Aldrich, Inc. However, the reliability of the study is considered to be low since the results were not reported in the form of a comprehensive study and only two replicates per concentration were tested, which significantly decreases the statistical power of the assay. Aluminum chloride can stimulate neurofibrillary changes in neurons of spinal cord and cerebrum in the developing rabbit′s brain. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Furthermore, only single plates were used for the vehicle control group, no positive control data and no historical control data were reported, and finally, the positive response was very and was not confirmed in a second experiment. RBC, WBC, PLT, Hb and Ht revealed significant decreases in the Al treated group compared to the control. reported limited information from an in vitro mammalian cell gene mutation assay. Aluminum chloride hexahydrate possess antimicrobial activity, when used in an aqueous form in an antiperspirant formulation. Most importantly, the reported histopathological findings are implausible: The animals were killed and their organs prepared for further examinations 24 hours after test substance administration. Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the, ACD/Labs Percepta Platform - PhysChem Module, Compounds with the same molecular formula, Search Google for structures with same skeleton, Soluble in water , alcohol, ether, glycerol, propylene glycol. A large number of in vitro and in vivo genotoxicity studies is available for anhydrous and basic aluminium chloride as well as for aluminium chloride hexahydrate; however, many of these show major deficiencies with regard to study design or experimental details and were disregarded after careful reviewing. In addition,the enzymatic activities of ALP, AST, ALT and LDH, and the levels of urea and uric acid significantly increased. Villarini et al. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. Lot and Batch Numbers can be found on a product's label Most importantly, the reported histopathological findings are implausible: The animals were killed and their organs prepared for further examinations 24 hours after test substance administration. Sodium citrate-acetic acid alcohol - air drying - Giemsa staining methodology was followed for the preparations of bone marrow cells. A 100-ml flask, A, contains a solution of electrolytes and some excess salt. Cultured human lymphocytes were treated with 5, 10, 15 and 25 uM aluminum chloride during the G1, G1/S, S (pulses of 1 and 6 h), and G2 phases of the cell cycle. Need larger quantities for your development, manufacturing or research applications? The study was therefore disregarded. Solubility: very soluble in water, freely soluble in ethanol (96 per cent), soluble in glycerol. To assess the genotoxic potential of aluminium chloride, several valid in vitro and two valid in vivo genotoxicity studies, partly conducted with other aluminium salts as supporting substances, were evaluated in a weight-of-evidence approach. Aluminium(III) chloride hexahydrate is a non-flammable; yellowish-white to colorless deliquescent granular crystals with slight HCl odor. Incompatible with acids.Note that decomposition of the anhydrous product, possibly caused by moisture leakinginto the container or being Aluminium chloride (AlCl3), also known as aluminium trichloride, describe compounds with the formula AlCl3(H2O)n (n = 0 or 6). Furthermore, severe pathological damages were established in both liver and kidneys of Al treated rats. No data are available about metabolic activation. Both are white solids, but samples are often contaminated with iron(III) chloride, giving a yellow color. Aluminium chloride is mainly produced using an exothermic reaction of two elements namely aluminium and chlorine. 1 mm Hg ( 100 °C) storage temp. Simultaneous administration of propolis attenuated the increased numbers of micronucleated hepatocytes induced by aluminium chloride. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. The authors report a significant increase in the number of MN in all treated groups. However, this study was diregarded because of the following main limitations: Significant damage in the liver was reported (increase in levels of serum enzymes and histological alterations in liver) whereas in a GLP OECD guideline 422 study on AlCl basic (CAS 1327-41-9), no liver damage and reduced ALP activity were observed up to 1000 mg/kg/day. 05427ES–021 - enter the lot number 05427ES without the filling-code Questo sito web si avvale di cookie affinché possiate usufruire della migliore esperienza sui nostri siti web. solubility. Also, no positive control was used. However, this study was conducted in non-GLP conditions and without standard methodology. It finds wide application in The test substance identity is unclear (indicated as "aluminium chloride hexahydrate" with CAS no 7446-70-0, but that CAS no. CopyCopied, JGDITNMASUZKPW-UHFFFAOYSA-K The study was therefore disregarded. Specimens injected with distilled water and their bone marrow fixed at the corresponding intervals served as controls. Cytotoxicity was indirectly measured by apoptosis. STBB0728K9 - enter the lot number STBB0728 without the filling-code Aggiornare Internet Explorer a una versione più recente.